Mon to Fri, 9 AM to 5 PM12313 Gold St, Omaha, NE 68144Care in English, Russian and Farsi(531) 571-3018

Mental health in Omaha, NE

Depression Treatment in Omaha, NE

Compassionate, board-certified care for major depressive disorder, persistent low mood, and treatment-resistant depression. Evidence-based evaluation, medication management, and access to Spravato.

  • Board-Certified Psychiatric Provider
  • Spravato® Available for Resistant Depression
  • Most Major Insurance Accepted
  • Serving Omaha, NE Community
4.9from 55 Google reviews
The hallway to the treatment rooms at ORIGEN Healthcare, with framed botanical prints
Symptom duration for diagnosis
at least two weeks
Time for antidepressants to work
two to six weeks
Definition of treatment-resistant depression
at least two antidepressants

You don't have to keep managing this alone

Depression can drain the energy out of everyday life: work, relationships, sleep, motivation, even simple decisions can start to feel heavy. At ORIGEN Healthcare, our depression treatment program starts with a thorough evaluation and an honest conversation about what you've been experiencing, so we can build a treatment plan that actually helps.

We combine psychiatric evaluation, medication management, and brief psychotherapy, and for patients who haven't found relief with standard antidepressants, we also offer Spravato (esketamine) therapy for treatment-resistant depression.

Why patients choose ORIGEN for depression treatment

Depression doesn't look the same for everyone, and it shouldn't be treated the same way for everyone. Our approach centers on an accurate evaluation and a plan built around your specific symptoms and history.

  • Comprehensive psychiatric evaluation to confirm diagnosis and severity
  • Individualized medication management, adjusted as you progress
  • Brief psychotherapy interventions alongside medical care
  • Spravato (esketamine) available for treatment-resistant depression
  • Culturally sensitive care, including services in Russian and Farsi
  • In person at our Omaha clinic
5 out of 5 stars

After years of not being properly treated for anxiety, depression, and ADHD, she helped me find the right combination of treatments, and she made sure I was part of the decision every step of the way. She really listens, takes side effect concerns seriously, and even coordinated with another doctor to make sure everything worked together safely.

Stephanie S.Google review, 2025

What is depression?

Depression, or major depressive disorder, is a medical condition marked by persistent sadness, loss of interest, and changes in energy, sleep, or appetite that last most of the day, nearly every day, for at least two weeks. It's more than temporary sadness: depression affects how the brain processes mood, motivation, and stress.

Depression can present differently depending on the person, and it includes related presentations such as seasonal affective disorder (SAD), postpartum depression, and persistent depressive disorder (a longer-lasting, lower-grade form).

Left untreated, depression can affect work, relationships, and physical health.

Signs you may benefit from depression treatment

You don't need to be at a breaking point to seek help. Many people benefit from an evaluation when symptoms start affecting daily life. A consultation with your provider is the best way to determine the right treatment path for you.

  • Persistent sadness, emptiness, or hopelessness
  • Loss of interest in activities you used to enjoy
  • Changes in sleep, appetite, or energy levels
  • Difficulty concentrating or making decisions
  • Feeling like you've tried medication before without real relief
  • A first-time evaluation or a second opinion on your current treatment

How depression treatment works

Getting started is straightforward. Here's what to expect from your first call to ongoing care.

  1. Initial consultation

    We review your symptom history, current medications, and treatment goals.

  2. Comprehensive evaluation

    A full psychiatric assessment confirms diagnosis and severity of depression.

  3. Personalized treatment plan

    Medication, brief therapy, or a combined approach, including Spravato if standard treatments haven't worked.

  4. Ongoing follow-up

    Regular visits track your progress and adjust treatment as needed.

Haven't found relief with standard antidepressants?

If you've tried multiple antidepressants without meaningful improvement, you may have treatment-resistant depression, and you may be a candidate for a different kind of treatment.

Spravato® (Esketamine) Therapy: ORIGEN Healthcare offers Spravato, an FDA-approved nasal treatment specifically for treatment-resistant depression, administered in a monitored clinical setting alongside your existing psychiatric care.

Start feeling like yourself again

Compassionate, board-certified depression treatment in Omaha, NE, including options for treatment-resistant depression. You don't have to navigate this alone.

Questions patients ask

How is depression diagnosed?

Depression is diagnosed through a clinical evaluation that reviews your symptoms, medical history, and how long you've been experiencing changes in mood, energy, or daily functioning. Standardized screening tools are often used to support diagnosis.

What is treatment-resistant depression?

Treatment-resistant depression refers to depression that hasn't responded adequately to at least two different antidepressant medications tried at appropriate doses. Options like Spravato (esketamine) are specifically approved for this group of patients.

Does depression treatment always require medication?

No. Treatment is individualized and may include medication, brief psychotherapy, lifestyle strategies, or a combination, depending on the severity and type of depression you're experiencing.

Is depression treatment covered by insurance?

Many depression evaluation and treatment services are covered by insurance, including medication management. Our team can help verify your specific benefits before your first appointment.

How long does it take for antidepressant medication to work?

Most antidepressants take two to six weeks to show noticeable improvement, though some people notice smaller changes sooner. Your provider will monitor your progress and adjust your plan as needed.

What if standard antidepressants haven't worked for me?

If you've tried multiple antidepressants without adequate relief, you may be a candidate for Spravato (esketamine) therapy, which we offer for treatment-resistant depression.

Nazira Usmanova, DNP, psychiatric nurse practitioner at ORIGEN Healthcare

Your provider

Nazira Usmanova, DNP

Doctor of Nursing Practice, Board-Certified Nurse Practitioner, with more than 14 years of clinical experience. She sees children from age 2, teens and adults, and speaks English, Russian and Farsi.

  • Psychiatric Mental Health NP (PMHNP-BC)
  • Pediatric NP (CPNP-PC)
  • Adult-Gerontology NP (AGNP-BC)
Meet Nazira

“True healing comes from listening, understanding, and walking alongside my patients in their journey to wellness.”

Nazira Usmanova

What patients say

4.9from 55 Google reviews
5 out of 5 stars

Before starting care with Nazira, I was in a very difficult place. She took the time to thoroughly evaluate me, leading to an accurate diagnosis and an effective treatment plan. Throughout the process, I faced many challenges, but she remained patient, dedicated, and never gave up on helping me improve.

Blake S.Google review, April 2026
5 out of 5 stars

With all of my different medication and mental health needs she always has a solution and she always knows how to offer support. Even if one medication works she has a secondary option or even a third option to replace what if something doesn't work.

Aunnika W.Google review, April 2026
5 out of 5 stars

I cannot recommend ORIGEN Healthcare enough. From the moment you walk in, you feel truly heard and supported. Dr. Nazira and the entire team are incredibly professional, compassionate, and thorough in their approach to mental wellness. They take the time to create a personalized plan that actually works.

Jonathan S.Google review, April 2026

Insurance we work with

We work with most major insurance plans. Coverage depends on your plan and the service, so our team checks your benefits with you before your visit.

Insurance and costs

Take the first step toward feeling better

You don’t have to figure it out alone. Tell us what is going on, and our care team will call you to find the right visit.

Mon to Fri, 9 AM to 5 PM12313 Gold St, Omaha, NE 68144